Tổng hợp và thử hoạt tính kháng khuẩn của các dẫn xuất dimethoxy naphthalene

Abstract

Four dimethoxynaphthalene derivatives (4a-b, 5a-b) were synthesized from 2.4- and 3.4- dimethoxybenzaldehyde through a two-step reaction sequence including the Stobbe condensation followed by cyclization to form naphthalene skeleton. Further functionalization was conducted by transferring the ester groups to the corresponding alcohol and acid carboxylic moieties. The structures of these compounds have been elucidated by H-NMR, C-NMR and DEPT. The antimicrobial activity of these products was evaluated by Agar diffusion method. These compounds showed activity against both Salmonella and E.coli at concentration of 8ug/mL.